Publications: Australian Animal Experimentation

@article{nokey,

title = {Scaffold-guided bone regeneration in large volume tibial segmental defects},

author = {Jan Henkel, Flavia Medeiros Savi, Arne Berner, Stephanie Fountain, Siamak Saifzadeh, Roland Steck, Devakar R Epari, Maria A Woodruff, Mark Knackstedt, Michael A Schuetz, Dietmar W Hutmacher},

url = {https://pubmed.ncbi.nlm.nih.gov/34461285/},

doi = {10.1016/j.bone.2021.116163},

year  = {2021},

date = {2021-12-01},

note = {Queensland University of Technology},

keywords = {Sheep},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Afferent Connections of Cytoarchitectural Area 6M and Surrounding Cortex in the Marmoset: Putative Homologues of the Supplementary and Pre-supplementary Motor Areas},

author = {Bakola S, Burman KJ, Bednarek S, Chan JM, Jermakow N, Worthy KK, Majka P, Rosa MGP.},

url = {https://pubmed.ncbi.nlm.nih.gov/34255833/},

year  = {2021},

date = {2021-11-23},

note = {Monash University},

keywords = {Marmosets, Non-human primates},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Anti-Drug antibodies in pigtailed macaques receiving HIV broadly neutralising antibody PGT121},

author = {Wen Shi Lee, Arnold Reynaldi, Thakshila Amarasena, Miles P. Davenport, Matthew S. Parsons and Stephen J. Kent},

doi = {10.3389/fimmu.2021.749891},

year  = {2021},

date = {2021-11-21},

urldate = {2021-11-21},

journal = {Frontiers in Immunology},

volume = {12},

note = {University of Melbourne},

keywords = {Macaque},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn},

author = {Kirat K. Chand, Jatin Patel, S. T. Bjorkman, Seen-Ling Sim, Stephanie M. Miller, Elliot Teo, Lara Jones, Jane Sun, Paul B. Colditz, Kiarash Khosrotehrani, Julie A. Wixey},

url = {https://www.nature.com/articles/s41536-021-00185-5.pdf},

doi = {https://doi.org/10.1038/s41536-021-00185-5},

year  = {2021},

date = {2021-11-18},

urldate = {2021-11-18},

abstract = {The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being common. There are no current treatments to protect the FGR newborn from lifelong neurological disorders. This study examines whether pure foetal mesenchymal stromal cells (MSC) and endothelial colony-forming cells (ECFC) from the human term placenta are neuroprotective through modulating neuroinflammation and supporting the brain vasculature. We determined that one dose of combined MSC-ECFCs (cECFC; 106 ECFC 106 MSC) on the first day of life to the newborn FGR piglet improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation and improved adverse neuronal and white matter changes present in the FGR newborn piglet brain. These findings could not be reproduced using MSCs alone. These results demonstrate cECFC treatment exerts beneficial effects on multiple cellular components in the FGR brain and may act as a neuroprotectant.},

note = {University of Queensland},

keywords = {piglets},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Visual cortical area MT is required for development of the dorsal stream and associated visuomotor behaviors},

author = {Kwan, Chang, Yu, Mundinano, Fox, Homman-Ludiye, & Bourne},

url = {https://pubmed.ncbi.nlm.nih.gov/34417331/},

year  = {2021},

date = {2021-09-29},

urldate = {2021-09-29},

abstract = {https://pubmed.ncbi.nlm.nih.gov/34417331/

},

note = {Monash University},

keywords = {Marmosets, Non-human primates},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction},

author = {Fujihara, K.M. et al},

url = {https://www.science.org/doi/10.1126/sciadv.abm9427},

year  = {2021},

date = {2021-09-14},

urldate = {2021-09-14},

journal = {Science},

volume = {8},

issue = {37},

note = {Peter MacCallum Cancer Centre, Melbourne},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = { A combination of epigenetic BET and CDK9 inhibitors for treatment of human melanoma},

author = {Emran, AA. et al},

url = {https://www.jidonline.org/article/S0022-202X(21)01121-0/fulltext},

year  = {2021},

date = {2021-09-01},

note = {Centenary Institute},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Adolescent oxytocin administration reduces depression-like behaviour induced by early life stress in adult male and female rats},

author = {Jade L Thornton, Nicholas A Everett, Paige Webb, Anita J Turner, Jennifer L Cornish, Sarah J Baracz},

url = {https://pubmed.ncbi.nlm.nih.gov/33567331/},

doi = {10.1016/j.pnpbp.2021.110279},

year  = {2021},

date = {2021-08-30},

urldate = {2021-08-30},

abstract = {Early life stress (ELS) exposure alters brain development, increasing vulnerability for mental illness in adulthood, including depression. Despite this association, there are no approved pharmacotherapies to protect against the emergence of mental illness resulting from ELS. Recent preclinical work showed that oxytocin (OT) administration in adulthood reduced depressive-like behaviour in male rats with a history of ELS. However, the ability of an OT treatment regime in adolescence, a critical developmental window for the OT system, to prevent the expression of depressive-like behaviours following ELS has not been investigated. Therefore, the present study aimed to determine whether chronic OT administration can ameliorate the enduring effects of ELS on depressive-like behaviours in both male and female rats. Following birth, Long Evans rat pups (N = 107) underwent maternal separation (MS) for either 15 min (MS15) or 6 h (MS360) on postnatal days (PND) 1-21. During adolescence (PND 28-42), rats received a daily injection of either OT (1 mg/kg) or saline. During adulthood (PND 57 onwards), effort-related motivation was measured using a model of effortful choice (EC), while behavioural despair was measured using the forced swim test (FST). Lastly, body and organ weights were measured to examine the physiological impacts of ELS and chronic OT administration. Overall, in both sexes, MS360 increased behavioural despair yet had no impact on effort-related motivation. Importantly, adolescent OT administration prevented the MS360-induced increase in behavioural despair in both males and females. Additionally, MS360 resulted in persistent reductions in body weight in both sexes post-weaning and increased spleen weight in males and adrenal weight in females. OT treatment had no impact on body weight in either sex, but prevented the MS-induced increase in adrenal gland weight in females. Overall, these findings have important implications for using oxytocin as a preventative pharmacotherapy after ELS.},

note = {Macquarie University},

keywords = {Rats},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Coformulation with Tattoo Ink for Immunological Assessment of Vaccine Immunogenicity in the Draining Lymph Node},

author = {Isaac M. Barber-Axthelm, Hannah G. Kelly, Robyn Esterbauer, Kathleen M. Wragg,

Anne M. Gibbon, Wen Shi Lee, Adam K. Wheatley, Stephen J. Kent, Hyon-Xhi Tan,

and Jennifer A. Juno

C},

doi = { https://doi.org/10.4049/jimmunol.2001299},

year  = {2021},

date = {2021-07-15},

urldate = {2021-07-15},

journal = {The Journal of Immunology},

volume = {207},

issue = {2},

pages = {735-744},

abstract = {Characterization of germinal center B and T cell responses yields critical insights into vaccine immunogenicity. Nonhuman primates are a key preclinical animal model for human vaccine development, allowing both lymph node (LN) and circulating immune responses to be longitudinally sampled for correlates of vaccine efficacy. However, patterns of vaccine Ag drainage via the lymphatics after i.m. immunization can be stochastic, driving uneven deposition between lymphoid sites and between individual LN within larger clusters. To improve the accurate isolation of Ag-exposed LN during biopsies and necropsies, we developed and validated a method for coformulating candidate vaccines with tattoo ink in both mice and pigtail macaques. This method allowed for direct visual identification of vaccine-draining LN and evaluation of relevant Ag-specific B and T cell responses by flow cytometry. This approach is a significant advancement in improving the assessment of vaccine-induced immunity in highly relevant nonhuman primate models.},

note = {Macaques - Monash Animal Research Platform Gippsland Field Station; Mice University of Melbourne},

keywords = {Macaque, Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia},

author = {Aridas, et al },

url = {https://pubmed.ncbi.nlm.nih.gov/34032315/},

year  = {2021},

date = {2021-06-20},

note = {Monash University, Hudson Institute of Medical Research},

keywords = {Sheep},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Lévy walk dynamics explain gamma burst patterns in primate cerebral cortex  },

author = {Liu Y, Long x, Martin PR, Solomon SG, Gong P.},

url = {https://pubmed.ncbi.nlm.nih.gov/34131276/},

year  = {2021},

date = {2021-06-15},

note = {University of Sydney},

keywords = {Non-human primates},

pubstate = {published},

tppubtype = {article}

}

@article{,

title = {The efficacy of a nanosynthetic bone graft substitute as a bone graft extender in rabbit posterolateral fusion},

author = {Jordan C. Conway, Rema A. Oliver, Tian Wang, Daniel J. Wills, Joe Herbert, Tom Buckland, William R. Walsh, Iain R. Gibson},

doi = {10.1016/j.spinee.2021.05.017},

year  = {2021},

date = {2021-05-19},

urldate = {2021-05-19},

volume = {21},

pages = {1925-1937},

publisher = {The Spine Journal},

note = {University of New South Wales},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury},

author = {Corrigan F, Cernak I, McAteer K, Hellewell SC, Rosenfeld JV, Turner RJ, & Fink R},

url = {https://www.nature.com/articles/s41598-021-88237-0},

year  = {2021},

date = {2021-04-23},

note = {University of Adelaide},

keywords = {Rats},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Neurochemical changes in the primate lateral geniculate nucleus following lesions of striate cortex in infancy and adulthood: implications for residual vision and blindsight},

author = {Atapour N, Worthy KM, Rosa MG.},

url = {https://link.springer.com/article/10.1007/s00429-021-02257-0},

year  = {2021},

date = {2021-03-20},

urldate = {2021-03-20},

note = {Monash University},

keywords = {Marmosets, Non-human primates},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = { Postpartum ovulation and early pregnancy in the menstruating spiny mouse},

author = {McKenna, J. Bellofiore B., Dimitriadis E., Temple-Smith , P.},

url = {https://www.nature.com/articles/s41598-021-84361-z},

year  = {2021},

date = {2021-03-05},

note = {Monash University},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Subcutaneous ω-Conotoxins Alleviate Mechanical Pain in Rodent Models of Acute Peripheral Neuropathy},

author = {Md Mahadhi Hasan, Hana Starobova, Alexander Mueller, Irina Vetter, Richard J Lewis},

doi = {10.3390/md19020106},

year  = {2021},

date = {2021-02-11},

urldate = {2021-02-11},

journal = {Marine Drugs},

abstract = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917901/

},

note = {University of Queensland},

keywords = {Mice, University of Queensland},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Mapping the neural circuitry of predator fear in the nonhuman primate},

author = {Quentin Montardy, William C Kwan, Inaki C Mundinano, Dylan M Fox, Liping Wang, Cornelius T Gross, James A Bourne},

url = {https://pubmed.ncbi.nlm.nih.gov/33263778/},

doi = {10.1007/s00429-020-02176-6},

year  = {2020},

date = {2020-12-02},

urldate = {2020-12-02},

abstract = {In rodents, innate and learned fear of predators depends on the medial hypothalamic defensive system, a conserved brain network that lies downstream of the amygdala and promotes avoidance via projections to the periaqueductal gray. Whether this network is involved in primate fear remains unknown. To address this, we provoked flight responses to a predator (moving snake) in the marmoset monkey under laboratory conditions. We combined c-Fos immunolabeling and anterograde/retrograde tracing to map the functional connectivity of the ventromedial hypothalamus, a core node in the medial hypothalamic defensive system. Our findings demonstrate that the ventromedial hypothalamus is recruited by predator exposure in primates and that anatomical connectivity of the rodent and primate medial hypothalamic defensive system are highly conserved.},

note = {Monash University},

keywords = {Marmosets, Non-human primates},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {A Comparative Study of Engineered Dermal Templates for Skin Wound Repair in a Mouse Model. },

author = {Banakh I, Cheshire P, Rahman M, Carmichael I, Jagadeesan P, Cameron NR, Cleland H. Akbarzadeh S.},

url = {https://www.mdpi.com/1422-0067/21/12/4508},

year  = {2020},

date = {2020-06-05},

note = {Monash University, Alfred Health},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice},

author = {Therese Freire, Alistair M. Senior, Ruth Perks, Tamara Pulpitel, Ximonie Clark, Amanda E. Brandon, Devin Wahl, Luke Hatchwell, David G. Le Couteur, Gregory J. Cooney, Mark Larance, Stephen J. Simpson, Samantha M. Solon-Biet},

url = {https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP278806},

doi = {https://doi.org/10.1113/JP278806},

year  = {2020},

date = {2020-03-21},

abstract = {There is growing interest in understanding the mechanistic significance and benefits of fasting physiology in combating obesity. Increasing the fasting phase of a normal day can promote restoration and repair mechanisms that occur during the post-absorptive period. Most studies exploring the effect of restricting food access on mitigating obesity have done so with a large bias towards the use of male mice. Here, we disentangle the roles of sex, food intake and food withdrawal in the response to a short-term daily fasting intervention, in which food was removed for 6 h in the dark/active phase of young, 8-week-old mice. We showed that the removal of food during the dark phase impaired glucose tolerance in males and females, possibly due to the circadian disruption induced by this feeding protocol. Although both sexes demonstrated similar patterns of food intake, body composition and various metabolic markers, there were clear sex differences in the magnitude and extent of these responses. While females displayed enhanced capacity for lipogenesis and triglyceride storage, they also had low fasting insulin levels and an increased potential for utilizing available energy sources such as fat for energy through β-oxidation. Our results highlight the intrinsic biological and metabolic disparities between male and female mice, emphasizing the growing need for the inclusion of both sexes in scientific research. Furthermore, our results illustrate sex-specific metabolic pathways that regulate lipogenesis, obesity and overall metabolic health.},

note = {Charles Perkins Centre, University of Sydney. },

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Sex specific metabolic responses to 6 hours fasting during the active phase in young mice},

author = {Therese Freire, Alistair M. Senior, Ruth Perks, Tamara Pulpitel, Ximonie Clark, Amanda E. Brandon, Devin Wahl, Luke Hatchwell, David G. Le Couteur, Gregory J. Cooney, Mark Larance, Stephen J. Simpson, Samantha M. Solon-Biet},

url = {https://pubmed.ncbi.nlm.nih.gov/32198893/},

year  = {2020},

date = {2020-03-21},

urldate = {2020-03-21},

note = {Charles Perkins Centre, University of Sydney},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}