This page includes a summary of recent publications (2019 onwards). This list is not exhaustive but a summary of the types of experimentation to which animals are subjected in Australian laboratories. More detailed profiles of Australian animal research can be found in our case studies.
Menon, D.R. et al
H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase Journal Article
In: Drug Resistance Updates, vol. 71, 2023, (University of Queensland).
@article{nokey,
title = {H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase},
author = {Menon, D.R. et al},
url = {https://www.sciencedirect.com/science/article/pii/S1368764623000766?via%3Dihub
},
year = {2023},
date = {2023-11-01},
urldate = {2023-11-01},
journal = {Drug Resistance Updates},
volume = {71},
note = {University of Queensland},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Vijayendra Dasari, et al
Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice Journal Article
In: Nature Communications, vol. 14, no. 4371, 2023, (QIMR Berghofer Medical Research Institute, Brisbane, Australia).
@article{nokey,
title = {Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice},
author = {Vijayendra Dasari, et al },
doi = {https://doi.org/10.1038/s41467-023-39770-1},
year = {2023},
date = {2023-08-08},
journal = {Nature Communications},
volume = {14},
number = {4371},
note = {QIMR Berghofer Medical Research Institute, Brisbane, Australia},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Lay Khoon Too, Weiyong Shen, Dario A. Protti, Atomu Sawatari, Dylan A. Black, Catherine A. Leamey, Jin Y. Huang, So-Ra Lee, Ashish E. Mathai, Leszek Lisowski, John Y. Lin, Mark C. Gillies & Matthew P. Simunovic
Optogenetic restoration of high sensitivity vision with bReaChES, a red-shifted channelrhodopsin Journal Article
In: Nature - Scientific Reports, vol. 12, no. 19312, 2022, (University of Sydney).
@article{nokey,
title = {Optogenetic restoration of high sensitivity vision with bReaChES, a red-shifted channelrhodopsin},
author = {Lay Khoon Too, Weiyong Shen, Dario A. Protti, Atomu Sawatari, Dylan A. Black, Catherine A. Leamey, Jin Y. Huang, So-Ra Lee, Ashish E. Mathai, Leszek Lisowski, John Y. Lin, Mark C. Gillies & Matthew P. Simunovic },
doi = {https://doi.org/10.1038/s41598-022-23572-4},
year = {2022},
date = {2022-11-11},
urldate = {2022-11-11},
journal = {Nature - Scientific Reports},
volume = {12},
number = {19312},
note = {University of Sydney},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Sydney M.A. Juan, Maria Daglas, Paul A. Adlard
In: European Journal of Neuroscience, 2022, (The Florey Institute of Neuroscience & Mental Health, The Melbourne Dementia Research Centre, the University of Melbourne.).
Abstract | Links | BibTeX | Tags: Mice
@article{nokey,
title = {Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1 month following repetitive mild traumatic brain injury},
author = {Sydney M.A. Juan, Maria Daglas, Paul A. Adlard},
doi = {10.1111/ejn.15752},
year = {2022},
date = {2022-06-29},
urldate = {2022-06-29},
journal = {European Journal of Neuroscience},
abstract = {Repetitive mild traumatic brain injury, commonly experienced following sports injuries, results in various secondary injury processes and is increasingly recognised as a risk factor for the development of neurodegenerative conditions such as chronic traumatic encephalopathy, which is characterised by tau pathology. We aimed to characterise the underlying pathological mechanisms that might contribute to the onset of neurodegeneration and behavioural changes in the less-explored subacute (1-month) period following single or repetitive controlled cortical impact injury (five impacts, 48 h apart) in 12-week-old male and female C57Bl6 mice. We conducted motor and cognitive testing, extensively characterised the status of tau and its regulatory proteins via western blot and quantified neuronal populations using stereology. We report that r-mTBI resulted in neurobehavioural deficits, gait impairments and anxiety-like behaviour at 1 month post-injury, effects not seen following a single injury. R-mTBI caused a significant increase in amyloid precursor protein, an increased trend towards tau phosphorylation and significant changes in kinase/phosphatase proteins that may promote a downstream increase in tau phosphorylation, but no changes in synaptic or neuroinflammatory markers. Lastly, we report neuronal loss in various brain regions following both single and repeat injuries. We demonstrate herein that repeated impacts are required to promote the initiation of a cascade of biochemical events that are consistent with the onset of neurodegeneration subacutely post-injury. Identifying the timeframe in which these changes occur and the pathological mechanisms involved will be crucial for the development of future therapeutics to prevent the onset or mitigate the progression of neurodegeneration following r-mTBI.},
note = {The Florey Institute of Neuroscience & Mental Health, The Melbourne Dementia Research Centre, the University of Melbourne.},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Hinds LA, Henry S, Van De Weyer N, Robinson F, Ruscoe WA, Brown R.
Acute oral toxicity of zinc phosphide: an assessment for wildhouse mice (Musmusculus) Journal Article
In: 2022.
Abstract | Links | BibTeX | Tags: CSIRO, Mice
@article{nokey,
title = {Acute oral toxicity of zinc phosphide: an assessment for wildhouse mice (Musmusculus)},
author = {Hinds LA, Henry S, Van De Weyer N, Robinson F, Ruscoe WA, Brown R.},
url = {https://onlinelibrary.wiley.com/doi/epdf/10.1111/1749-4877.12666},
doi = {10.1111/1749-4877.12666},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
abstract = {Irregular plagues of house mice, Mus musculus, incur major economic impacts on agricultural production in Australia. The efficacy of zinc phosphide (ZnP), the only registered broadacre control agent for mice, is reported as increasingly variable. Have mice become less sensitive over time or are they taking a sub-lethal dose and developing aversion? In this laboratory study, the sensitivity of mice (wild caught; outbred laboratory strain) was assessed using oral gavage of a range of ZnP concentrations. The estimated LD50values (72–79 mg ZnP/kg body weight)were similar for each mouse group but are significantly higher than previously reported. The willingness of mice to consume ZnP-coated grains was determined. ZnP-coated grains (50 g ZnP/kg grain) presented in the absence of alternative food were consumed and 94% of wild mice died. Mice provided with alternative food and ZnP-coated wheat grains (either 25 or 50 g ZnP/kg grain) consumed toxic and non-toxic grains, and mortality was lower(33–55%). If a sublethal amount of ZnP-coated grain was consumed, aversion occurred, mostly when alternative food was present. The sensitivity of wild house mice to ZnP in Australia is significantly lower than previously assumed. Under laboratory conditions, ZnP-coated grains coated with a new higher dose (50 g ZnP/kg grain) were readily consumed. Consumption of toxic grain occurred when alternative food was available but was decreased. Our unambiguous findings for house mice indicate a re-assessment of the ZnP loading for baits used for control of many rodents around the world may be warranted.},
keywords = {CSIRO, Mice},
pubstate = {published},
tppubtype = {article}
}
Mills, S.A, Jobling A.I., Dixon M.A., Fletcher E.L.
Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy Journal Article
In: 2021, (University of Melbourne).
@article{nokey,
title = {Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy},
author = {Mills, S.A, Jobling A.I., Dixon M.A., Fletcher E.L.},
url = {https://www.pnas.org/doi/10.1073/pnas.2112561118},
year = {2021},
date = {2021-12-13},
urldate = {2021-12-13},
note = {University of Melbourne},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Fujihara, K.M. et al
Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction Journal Article
In: Science, vol. 8, iss. 37, 2021, (Peter MacCallum Cancer Centre, Melbourne).
@article{nokey,
title = {Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction},
author = {Fujihara, K.M. et al},
url = {https://www.science.org/doi/10.1126/sciadv.abm9427},
year = {2021},
date = {2021-09-14},
urldate = {2021-09-14},
journal = {Science},
volume = {8},
issue = {37},
note = {Peter MacCallum Cancer Centre, Melbourne},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Emran, AA. et al
A combination of epigenetic BET and CDK9 inhibitors for treatment of human melanoma Journal Article
In: 2021, (Centenary Institute).
@article{nokey,
title = { A combination of epigenetic BET and CDK9 inhibitors for treatment of human melanoma},
author = {Emran, AA. et al},
url = {https://www.jidonline.org/article/S0022-202X(21)01121-0/fulltext},
year = {2021},
date = {2021-09-01},
note = {Centenary Institute},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Isaac M. Barber-Axthelm, Hannah G. Kelly, Robyn Esterbauer, Kathleen M. Wragg, Anne M. Gibbon, Wen Shi Lee, Adam K. Wheatley, Stephen J. Kent, Hyon-Xhi Tan, and Jennifer A. Juno C
Coformulation with Tattoo Ink for Immunological Assessment of Vaccine Immunogenicity in the Draining Lymph Node Journal Article
In: The Journal of Immunology, vol. 207, iss. 2, pp. 735-744, 2021, (Macaques - Monash Animal Research Platform Gippsland Field Station; Mice University of Melbourne).
Abstract | Links | BibTeX | Tags: Macaque, Mice
@article{nokey,
title = {Coformulation with Tattoo Ink for Immunological Assessment of Vaccine Immunogenicity in the Draining Lymph Node},
author = {Isaac M. Barber-Axthelm, Hannah G. Kelly, Robyn Esterbauer, Kathleen M. Wragg,
Anne M. Gibbon, Wen Shi Lee, Adam K. Wheatley, Stephen J. Kent, Hyon-Xhi Tan,
and Jennifer A. Juno
C},
doi = { https://doi.org/10.4049/jimmunol.2001299},
year = {2021},
date = {2021-07-15},
urldate = {2021-07-15},
journal = {The Journal of Immunology},
volume = {207},
issue = {2},
pages = {735-744},
abstract = {Characterization of germinal center B and T cell responses yields critical insights into vaccine immunogenicity. Nonhuman primates are a key preclinical animal model for human vaccine development, allowing both lymph node (LN) and circulating immune responses to be longitudinally sampled for correlates of vaccine efficacy. However, patterns of vaccine Ag drainage via the lymphatics after i.m. immunization can be stochastic, driving uneven deposition between lymphoid sites and between individual LN within larger clusters. To improve the accurate isolation of Ag-exposed LN during biopsies and necropsies, we developed and validated a method for coformulating candidate vaccines with tattoo ink in both mice and pigtail macaques. This method allowed for direct visual identification of vaccine-draining LN and evaluation of relevant Ag-specific B and T cell responses by flow cytometry. This approach is a significant advancement in improving the assessment of vaccine-induced immunity in highly relevant nonhuman primate models.},
note = {Macaques - Monash Animal Research Platform Gippsland Field Station; Mice University of Melbourne},
keywords = {Macaque, Mice},
pubstate = {published},
tppubtype = {article}
}
McKenna, J. Bellofiore B., Dimitriadis E., Temple-Smith , P.
Postpartum ovulation and early pregnancy in the menstruating spiny mouse Journal Article
In: 2021, (Monash University).
@article{nokey,
title = { Postpartum ovulation and early pregnancy in the menstruating spiny mouse},
author = {McKenna, J. Bellofiore B., Dimitriadis E., Temple-Smith , P.},
url = {https://www.nature.com/articles/s41598-021-84361-z},
year = {2021},
date = {2021-03-05},
note = {Monash University},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Md Mahadhi Hasan, Hana Starobova, Alexander Mueller, Irina Vetter, Richard J Lewis
Subcutaneous ω-Conotoxins Alleviate Mechanical Pain in Rodent Models of Acute Peripheral Neuropathy Journal Article
In: Marine Drugs, 2021, (University of Queensland).
Abstract | Links | BibTeX | Tags: Mice, University of Queensland
@article{nokey,
title = {Subcutaneous ω-Conotoxins Alleviate Mechanical Pain in Rodent Models of Acute Peripheral Neuropathy},
author = {Md Mahadhi Hasan, Hana Starobova, Alexander Mueller, Irina Vetter, Richard J Lewis},
doi = {10.3390/md19020106},
year = {2021},
date = {2021-02-11},
urldate = {2021-02-11},
journal = {Marine Drugs},
abstract = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917901/
},
note = {University of Queensland},
keywords = {Mice, University of Queensland},
pubstate = {published},
tppubtype = {article}
}
Banakh I, Cheshire P, Rahman M, Carmichael I, Jagadeesan P, Cameron NR, Cleland H. Akbarzadeh S.
A Comparative Study of Engineered Dermal Templates for Skin Wound Repair in a Mouse Model. Journal Article
In: 2020, (Monash University, Alfred Health).
@article{nokey,
title = {A Comparative Study of Engineered Dermal Templates for Skin Wound Repair in a Mouse Model. },
author = {Banakh I, Cheshire P, Rahman M, Carmichael I, Jagadeesan P, Cameron NR, Cleland H. Akbarzadeh S.},
url = {https://www.mdpi.com/1422-0067/21/12/4508},
year = {2020},
date = {2020-06-05},
note = {Monash University, Alfred Health},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Therese Freire, Alistair M. Senior, Ruth Perks, Tamara Pulpitel, Ximonie Clark, Amanda E. Brandon, Devin Wahl, Luke Hatchwell, David G. Le Couteur, Gregory J. Cooney, Mark Larance, Stephen J. Simpson, Samantha M. Solon-Biet
Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice Journal Article
In: 2020, (Charles Perkins Centre, University of Sydney. ).
Abstract | Links | BibTeX | Tags: Mice
@article{nokey,
title = {Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice},
author = {Therese Freire, Alistair M. Senior, Ruth Perks, Tamara Pulpitel, Ximonie Clark, Amanda E. Brandon, Devin Wahl, Luke Hatchwell, David G. Le Couteur, Gregory J. Cooney, Mark Larance, Stephen J. Simpson, Samantha M. Solon-Biet},
url = {https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP278806},
doi = {https://doi.org/10.1113/JP278806},
year = {2020},
date = {2020-03-21},
abstract = {There is growing interest in understanding the mechanistic significance and benefits of fasting physiology in combating obesity. Increasing the fasting phase of a normal day can promote restoration and repair mechanisms that occur during the post-absorptive period. Most studies exploring the effect of restricting food access on mitigating obesity have done so with a large bias towards the use of male mice. Here, we disentangle the roles of sex, food intake and food withdrawal in the response to a short-term daily fasting intervention, in which food was removed for 6 h in the dark/active phase of young, 8-week-old mice. We showed that the removal of food during the dark phase impaired glucose tolerance in males and females, possibly due to the circadian disruption induced by this feeding protocol. Although both sexes demonstrated similar patterns of food intake, body composition and various metabolic markers, there were clear sex differences in the magnitude and extent of these responses. While females displayed enhanced capacity for lipogenesis and triglyceride storage, they also had low fasting insulin levels and an increased potential for utilizing available energy sources such as fat for energy through β-oxidation. Our results highlight the intrinsic biological and metabolic disparities between male and female mice, emphasizing the growing need for the inclusion of both sexes in scientific research. Furthermore, our results illustrate sex-specific metabolic pathways that regulate lipogenesis, obesity and overall metabolic health.},
note = {Charles Perkins Centre, University of Sydney. },
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Therese Freire, Alistair M. Senior, Ruth Perks, Tamara Pulpitel, Ximonie Clark, Amanda E. Brandon, Devin Wahl, Luke Hatchwell, David G. Le Couteur, Gregory J. Cooney, Mark Larance, Stephen J. Simpson, Samantha M. Solon-Biet
Sex specific metabolic responses to 6 hours fasting during the active phase in young mice Journal Article
In: 2020, (Charles Perkins Centre, University of Sydney).
@article{nokey,
title = {Sex specific metabolic responses to 6 hours fasting during the active phase in young mice},
author = {Therese Freire, Alistair M. Senior, Ruth Perks, Tamara Pulpitel, Ximonie Clark, Amanda E. Brandon, Devin Wahl, Luke Hatchwell, David G. Le Couteur, Gregory J. Cooney, Mark Larance, Stephen J. Simpson, Samantha M. Solon-Biet},
url = {https://pubmed.ncbi.nlm.nih.gov/32198893/},
year = {2020},
date = {2020-03-21},
urldate = {2020-03-21},
note = {Charles Perkins Centre, University of Sydney},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Manion J., Khong T., Harney D., Littleboy J.B., Ruan T., Loo L., Costigan M., Larance M., Caron L., Neely G.G.
Human induced pluripotent stem cell-derived GABAergic interneuron transplants attenuate neuropathic pain Journal Article
In: 2020, (University of Sydney et al).
@article{nokey,
title = {Human induced pluripotent stem cell-derived GABAergic interneuron transplants attenuate neuropathic pain},
author = {Manion J., Khong T., Harney D., Littleboy J.B., Ruan T., Loo L., Costigan M., Larance M., Caron L., Neely G.G.},
url = {https://pubmed.ncbi.nlm.nih.gov/31972853/},
year = {2020},
date = {2020-02-01},
note = {University of Sydney et al},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Nguyen T, Li GE, Chen H, Cranfield CC, McGrath KC, GorrieCA.
Neurological effects in the offspring after switching from tobacco cigarettes to e-cigarettes during pregnancy in a mouse model Journal Article
In: 2019, (University of Technology Sydney).
@article{nokey,
title = {Neurological effects in the offspring after switching from tobacco cigarettes to e-cigarettes during pregnancy in a mouse model},
author = {Nguyen T, Li GE, Chen H, Cranfield CC, McGrath KC, GorrieCA.},
url = {https://pubmed.ncbi.nlm.nih.gov/31505003/},
year = {2019},
date = {2019-08-29},
note = {University of Technology Sydney},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}
Liu B, Page AJ, Hutchison AT, Wittert GA, Heilbronn LK.
Intermittent fasting increasing energy expenditure and promotes adipose tissue browning in mice Journal Article
In: 2019, (University of Adelaide, South Australian Health and Medical Research Institute).
@article{nokey,
title = { Intermittent fasting increasing energy expenditure and promotes adipose tissue browning in mice},
author = { Liu B, Page AJ, Hutchison AT, Wittert GA, Heilbronn LK.},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0899900719300462?via%3Dihub},
year = {2019},
date = {2019-06-01},
note = {University of Adelaide, South Australian Health and Medical Research Institute},
keywords = {Mice},
pubstate = {published},
tppubtype = {article}
}