This page includes a summary of recent publications (2019 onwards). This list is not exhaustive but a summary of the types of experimentation to which animals are subjected in Australian laboratories. More detailed profiles of Australian animal research can be found in our case studies.
1.
Pablo Miguel Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L Braine, Rhys D Brady, Mujun Sun, Cheng Huang, Christopher K Barlow, Anup D Shah, Ralf B Schittenhelm, Richelle Mychasiuk, Nigel C Jones, Sandy R Shultz, Terence J O’Brien
Modifying effects of sodium selenate in a model of drug resistant, temporal lobe epilepsy Journal Article
In: eLife Sciences, 2023, ISSN: 2050-084X.
@article{nokey,
title = {Modifying effects of sodium selenate in a model of drug resistant, temporal lobe epilepsy},
author = {Pablo Miguel Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L Braine, Rhys D Brady, Mujun Sun, Cheng Huang, Christopher K Barlow, Anup D Shah, Ralf B Schittenhelm, Richelle Mychasiuk, Nigel C Jones, Sandy R Shultz, Terence J O’Brien },
url = {https://elifesciences.org/articles/78877},
doi = { https://doi.org/10.7554/eLife.78877},
issn = {2050-084X},
year = {2023},
date = {2023-03-09},
urldate = {2023-03-09},
journal = {eLife Sciences},
keywords = {Rats},
pubstate = {published},
tppubtype = {article}
}
2.
Benjamin Aliphon ,Twain Dai, Jessica Moretti, Marissa Penrose-Menz, Wilhelmina H A M Mulders, Dominique Blache, Jennifer Rodger
A repeated measures cognitive affective bias test in rats: comparison with forced swim test Journal Article
In: Psychopharmacology (Berl) , 2022, (University of Western Australia).
Abstract | Links | BibTeX | Tags: Rats
@article{nokey,
title = {A repeated measures cognitive affective bias test in rats: comparison with forced swim test},
author = {Benjamin Aliphon ,Twain Dai, Jessica Moretti, Marissa Penrose-Menz, Wilhelmina H A M Mulders, Dominique Blache, Jennifer Rodger},
url = {https://pubmed.ncbi.nlm.nih.gov/36450831/},
doi = {10.1007/s00213-022-06281-8},
year = {2022},
date = {2022-12-01},
urldate = {2022-12-01},
journal = {Psychopharmacology (Berl) },
abstract = {Objectives: This study aimed to validate a repeated measures cognitive affective bias (CAB) test in a rat model of chronic stress and compare CAB with forced swim test (FST) measures.
Method: Male and female Sprague Dawley rats were trained to associate large and small rewards with scent, spatial, and tactile cues, and their response to an ambiguous tactile stimulus tested. Rats underwent weekly CAB testing for 4 weeks with no intervention, or for 2 weeks of chronic restraint stress (CRS), followed by 2 weeks of fluoxetine, vehicle, or no treatment. CRS rats also underwent the FST at selected timepoints.},
note = {University of Western Australia},
keywords = {Rats},
pubstate = {published},
tppubtype = {article}
}
Objectives: This study aimed to validate a repeated measures cognitive affective bias (CAB) test in a rat model of chronic stress and compare CAB with forced swim test (FST) measures.
Method: Male and female Sprague Dawley rats were trained to associate large and small rewards with scent, spatial, and tactile cues, and their response to an ambiguous tactile stimulus tested. Rats underwent weekly CAB testing for 4 weeks with no intervention, or for 2 weeks of chronic restraint stress (CRS), followed by 2 weeks of fluoxetine, vehicle, or no treatment. CRS rats also underwent the FST at selected timepoints.
Method: Male and female Sprague Dawley rats were trained to associate large and small rewards with scent, spatial, and tactile cues, and their response to an ambiguous tactile stimulus tested. Rats underwent weekly CAB testing for 4 weeks with no intervention, or for 2 weeks of chronic restraint stress (CRS), followed by 2 weeks of fluoxetine, vehicle, or no treatment. CRS rats also underwent the FST at selected timepoints.
3.
Shannon Thomson, Yik Lung Chan, Chenju Yi Baoming Wang, Rita Machaalani, Brian G Oliver Catherine A Gorrie, Hui Chen
Impact of High Fat Consumption on Neurological Functions after Traumatic Brain Injury in Rats Journal Article
In: 2022, (University of Technology Sydney).
@article{nokey,
title = {Impact of High Fat Consumption on Neurological Functions after Traumatic Brain Injury in Rats},
author = {Shannon Thomson, Yik Lung Chan, Chenju Yi Baoming Wang, Rita Machaalani, Brian G Oliver Catherine A Gorrie, Hui Chen },
url = {https://pubmed.ncbi.nlm.nih.gov/35658673/},
year = {2022},
date = {2022-07-14},
urldate = {2022-07-14},
note = {University of Technology Sydney},
keywords = {Rats},
pubstate = {published},
tppubtype = {article}
}
4.
Bhedita J. Seewoo, Lauren A. Hennessy, Liz A. Jaeschke, Leah A. Mackie, Sarah J. Etherington, Sarah A. Dunlop, Paul E. Croarkin,, Jennifer Rodger
A Preclinical Study of Standard Versus Accelerated Transcranial Magnetic Stimulation for Depression in Adolescents Journal Article
In: vol. 32, no. 3, 2022, (University of Western Australia, Perron Institute for Neurological & Translational Science, WA).
Abstract | Links | BibTeX | Tags: Rats
@article{nokey,
title = {A Preclinical Study of Standard Versus Accelerated Transcranial Magnetic Stimulation for Depression in Adolescents},
author = {Bhedita J. Seewoo, Lauren A. Hennessy, Liz A. Jaeschke, Leah A. Mackie, Sarah J. Etherington, Sarah A. Dunlop, Paul E. Croarkin, and Jennifer Rodger},
doi = {10.1089/cap.2021.0100},
year = {2022},
date = {2022-04-18},
urldate = {2022-04-18},
volume = {32},
number = {3},
abstract = {Abstract
Objective: Ongoing studies are focused on adapting transcranial magnetic stimulation (TMS) for the treatment of major depressive disorder in adolescent humans. Most protocols in adolescent humans to date have delivered daily 10 Hz prefrontal stimulation with mixed results. Novel TMS dosing strategies such as accelerated TMS have recently been considered. There are knowledge gaps related to the potential clinical and pragmatic advantages of accelerated TMS. This pilot study compared the behavioral effects of a standard daily and accelerated low-intensity TMS (LI-TMS) protocol in an adolescent murine model of depression.
Methods: Male adolescent Sprague Dawley rats were placed in transparent plexiglass tubes for 2.5 hours daily for 13 days as part of a study to validate the chronic restraint stress (CRS) protocol. Rats subsequently received 10 minutes of active or sham 10 Hz LI-TMS daily for 2 weeks (standard) or three times daily for 1 week (accelerated). Behavior was assessed using the elevated plus maze and forced swim test (FST). Hippocampal neurogenesis was assessed by injection of the thymidine analogue 5-ethynyl-2′-deoxyuridine at the end of LI-TMS treatment (2 weeks standard, 1 week accelerated), followed by postmortem histological analysis.},
note = {University of Western Australia, Perron Institute for Neurological & Translational Science, WA},
keywords = {Rats},
pubstate = {published},
tppubtype = {article}
}
Abstract
Objective: Ongoing studies are focused on adapting transcranial magnetic stimulation (TMS) for the treatment of major depressive disorder in adolescent humans. Most protocols in adolescent humans to date have delivered daily 10 Hz prefrontal stimulation with mixed results. Novel TMS dosing strategies such as accelerated TMS have recently been considered. There are knowledge gaps related to the potential clinical and pragmatic advantages of accelerated TMS. This pilot study compared the behavioral effects of a standard daily and accelerated low-intensity TMS (LI-TMS) protocol in an adolescent murine model of depression.
Methods: Male adolescent Sprague Dawley rats were placed in transparent plexiglass tubes for 2.5 hours daily for 13 days as part of a study to validate the chronic restraint stress (CRS) protocol. Rats subsequently received 10 minutes of active or sham 10 Hz LI-TMS daily for 2 weeks (standard) or three times daily for 1 week (accelerated). Behavior was assessed using the elevated plus maze and forced swim test (FST). Hippocampal neurogenesis was assessed by injection of the thymidine analogue 5-ethynyl-2′-deoxyuridine at the end of LI-TMS treatment (2 weeks standard, 1 week accelerated), followed by postmortem histological analysis.
Objective: Ongoing studies are focused on adapting transcranial magnetic stimulation (TMS) for the treatment of major depressive disorder in adolescent humans. Most protocols in adolescent humans to date have delivered daily 10 Hz prefrontal stimulation with mixed results. Novel TMS dosing strategies such as accelerated TMS have recently been considered. There are knowledge gaps related to the potential clinical and pragmatic advantages of accelerated TMS. This pilot study compared the behavioral effects of a standard daily and accelerated low-intensity TMS (LI-TMS) protocol in an adolescent murine model of depression.
Methods: Male adolescent Sprague Dawley rats were placed in transparent plexiglass tubes for 2.5 hours daily for 13 days as part of a study to validate the chronic restraint stress (CRS) protocol. Rats subsequently received 10 minutes of active or sham 10 Hz LI-TMS daily for 2 weeks (standard) or three times daily for 1 week (accelerated). Behavior was assessed using the elevated plus maze and forced swim test (FST). Hippocampal neurogenesis was assessed by injection of the thymidine analogue 5-ethynyl-2′-deoxyuridine at the end of LI-TMS treatment (2 weeks standard, 1 week accelerated), followed by postmortem histological analysis.
5.
Mawj Mandwie, Jordan A Piper, Catherine A Gorrie, Kevin A Keay, Giuseppe Musumeci , Ghaith Al-Badri, Alessandro Castorina
Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury Journal Article
In: 2022, (University of Technology Sydney).
@article{nokey,
title = {Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury},
author = {Mawj Mandwie, Jordan A Piper, Catherine A Gorrie, Kevin A Keay, Giuseppe Musumeci , Ghaith Al-Badri, Alessandro Castorina},
url = {https://pubmed.ncbi.nlm.nih.gov/34269213/},
year = {2022},
date = {2022-02-17},
urldate = {2022-02-17},
note = {University of Technology Sydney},
keywords = {Rats},
pubstate = {published},
tppubtype = {article}
}
6.
Laura K Milton, Paul N Mirabella, Erika Greaves, David C Spanswick, Maarten van den Buuse, Brian J Oldfield , Claire J Foldi
Suppression of Corticostriatal Circuit Activity Improves Cognitive Flexibility and Prevents Body Weight Loss in Activity-Based Anorexia in Rats Journal Article
In: 2021, (Monash Biomedicine Discovery Institute, Monash University et al. ).
@article{nokey,
title = {Suppression of Corticostriatal Circuit Activity Improves Cognitive Flexibility and Prevents Body Weight Loss in Activity-Based Anorexia in Rats},
author = {Laura K Milton, Paul N Mirabella, Erika Greaves, David C Spanswick, Maarten van den Buuse, Brian J Oldfield , Claire J Foldi },
url = {https://pubmed.ncbi.nlm.nih.gov/32892984/},
year = {2021},
date = {2021-12-15},
urldate = {2021-12-15},
note = {Monash Biomedicine Discovery Institute, Monash University et al.
},
keywords = {Rats},
pubstate = {published},
tppubtype = {article}
}
7.
Jade L Thornton, Nicholas A Everett, Paige Webb, Anita J Turner, Jennifer L Cornish, Sarah J Baracz
Adolescent oxytocin administration reduces depression-like behaviour induced by early life stress in adult male and female rats Journal Article
In: 2021, (Macquarie University).
Abstract | Links | BibTeX | Tags: Rats
@article{nokey,
title = {Adolescent oxytocin administration reduces depression-like behaviour induced by early life stress in adult male and female rats},
author = {Jade L Thornton, Nicholas A Everett, Paige Webb, Anita J Turner, Jennifer L Cornish, Sarah J Baracz},
url = {https://pubmed.ncbi.nlm.nih.gov/33567331/},
doi = {10.1016/j.pnpbp.2021.110279},
year = {2021},
date = {2021-08-30},
urldate = {2021-08-30},
abstract = {Early life stress (ELS) exposure alters brain development, increasing vulnerability for mental illness in adulthood, including depression. Despite this association, there are no approved pharmacotherapies to protect against the emergence of mental illness resulting from ELS. Recent preclinical work showed that oxytocin (OT) administration in adulthood reduced depressive-like behaviour in male rats with a history of ELS. However, the ability of an OT treatment regime in adolescence, a critical developmental window for the OT system, to prevent the expression of depressive-like behaviours following ELS has not been investigated. Therefore, the present study aimed to determine whether chronic OT administration can ameliorate the enduring effects of ELS on depressive-like behaviours in both male and female rats. Following birth, Long Evans rat pups (N = 107) underwent maternal separation (MS) for either 15 min (MS15) or 6 h (MS360) on postnatal days (PND) 1-21. During adolescence (PND 28-42), rats received a daily injection of either OT (1 mg/kg) or saline. During adulthood (PND 57 onwards), effort-related motivation was measured using a model of effortful choice (EC), while behavioural despair was measured using the forced swim test (FST). Lastly, body and organ weights were measured to examine the physiological impacts of ELS and chronic OT administration. Overall, in both sexes, MS360 increased behavioural despair yet had no impact on effort-related motivation. Importantly, adolescent OT administration prevented the MS360-induced increase in behavioural despair in both males and females. Additionally, MS360 resulted in persistent reductions in body weight in both sexes post-weaning and increased spleen weight in males and adrenal weight in females. OT treatment had no impact on body weight in either sex, but prevented the MS-induced increase in adrenal gland weight in females. Overall, these findings have important implications for using oxytocin as a preventative pharmacotherapy after ELS.},
note = {Macquarie University},
keywords = {Rats},
pubstate = {published},
tppubtype = {article}
}
Early life stress (ELS) exposure alters brain development, increasing vulnerability for mental illness in adulthood, including depression. Despite this association, there are no approved pharmacotherapies to protect against the emergence of mental illness resulting from ELS. Recent preclinical work showed that oxytocin (OT) administration in adulthood reduced depressive-like behaviour in male rats with a history of ELS. However, the ability of an OT treatment regime in adolescence, a critical developmental window for the OT system, to prevent the expression of depressive-like behaviours following ELS has not been investigated. Therefore, the present study aimed to determine whether chronic OT administration can ameliorate the enduring effects of ELS on depressive-like behaviours in both male and female rats. Following birth, Long Evans rat pups (N = 107) underwent maternal separation (MS) for either 15 min (MS15) or 6 h (MS360) on postnatal days (PND) 1-21. During adolescence (PND 28-42), rats received a daily injection of either OT (1 mg/kg) or saline. During adulthood (PND 57 onwards), effort-related motivation was measured using a model of effortful choice (EC), while behavioural despair was measured using the forced swim test (FST). Lastly, body and organ weights were measured to examine the physiological impacts of ELS and chronic OT administration. Overall, in both sexes, MS360 increased behavioural despair yet had no impact on effort-related motivation. Importantly, adolescent OT administration prevented the MS360-induced increase in behavioural despair in both males and females. Additionally, MS360 resulted in persistent reductions in body weight in both sexes post-weaning and increased spleen weight in males and adrenal weight in females. OT treatment had no impact on body weight in either sex, but prevented the MS-induced increase in adrenal gland weight in females. Overall, these findings have important implications for using oxytocin as a preventative pharmacotherapy after ELS.
8.
Corrigan F, Cernak I, McAteer K, Hellewell SC, Rosenfeld JV, Turner RJ, & Fink R
NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury Journal Article
In: 2021, (University of Adelaide).
@article{nokey,
title = {NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury},
author = {Corrigan F, Cernak I, McAteer K, Hellewell SC, Rosenfeld JV, Turner RJ, & Fink R},
url = {https://www.nature.com/articles/s41598-021-88237-0},
year = {2021},
date = {2021-04-23},
note = {University of Adelaide},
keywords = {Rats},
pubstate = {published},
tppubtype = {article}
}