Publications: Australian Animal Experimentation

@article{nokey,

title = {A Comparative Study of Engineered Dermal Templates for Skin Wound Repair in a Mouse Model. },

author = {Banakh I, Cheshire P, Rahman M, Carmichael I, Jagadeesan P, Cameron NR, Cleland H. Akbarzadeh S.},

url = {https://www.mdpi.com/1422-0067/21/12/4508},

year  = {2020},

date = {2020-06-05},

note = {Monash University, Alfred Health},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice},

author = {Therese Freire, Alistair M. Senior, Ruth Perks, Tamara Pulpitel, Ximonie Clark, Amanda E. Brandon, Devin Wahl, Luke Hatchwell, David G. Le Couteur, Gregory J. Cooney, Mark Larance, Stephen J. Simpson, Samantha M. Solon-Biet},

url = {https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP278806},

doi = {https://doi.org/10.1113/JP278806},

year  = {2020},

date = {2020-03-21},

abstract = {There is growing interest in understanding the mechanistic significance and benefits of fasting physiology in combating obesity. Increasing the fasting phase of a normal day can promote restoration and repair mechanisms that occur during the post-absorptive period. Most studies exploring the effect of restricting food access on mitigating obesity have done so with a large bias towards the use of male mice. Here, we disentangle the roles of sex, food intake and food withdrawal in the response to a short-term daily fasting intervention, in which food was removed for 6 h in the dark/active phase of young, 8-week-old mice. We showed that the removal of food during the dark phase impaired glucose tolerance in males and females, possibly due to the circadian disruption induced by this feeding protocol. Although both sexes demonstrated similar patterns of food intake, body composition and various metabolic markers, there were clear sex differences in the magnitude and extent of these responses. While females displayed enhanced capacity for lipogenesis and triglyceride storage, they also had low fasting insulin levels and an increased potential for utilizing available energy sources such as fat for energy through β-oxidation. Our results highlight the intrinsic biological and metabolic disparities between male and female mice, emphasizing the growing need for the inclusion of both sexes in scientific research. Furthermore, our results illustrate sex-specific metabolic pathways that regulate lipogenesis, obesity and overall metabolic health.},

note = {Charles Perkins Centre, University of Sydney. },

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Sex specific metabolic responses to 6 hours fasting during the active phase in young mice},

author = {Therese Freire, Alistair M. Senior, Ruth Perks, Tamara Pulpitel, Ximonie Clark, Amanda E. Brandon, Devin Wahl, Luke Hatchwell, David G. Le Couteur, Gregory J. Cooney, Mark Larance, Stephen J. Simpson, Samantha M. Solon-Biet},

url = {https://pubmed.ncbi.nlm.nih.gov/32198893/},

year  = {2020},

date = {2020-03-21},

urldate = {2020-03-21},

note = {Charles Perkins Centre, University of Sydney},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Human induced pluripotent stem cell-derived GABAergic interneuron transplants attenuate neuropathic pain},

author = {Manion J., Khong T., Harney D., Littleboy J.B., Ruan T., Loo L., Costigan M., Larance M., Caron L., Neely G.G.},

url = {https://pubmed.ncbi.nlm.nih.gov/31972853/},

year  = {2020},

date = {2020-02-01},

note = {University of Sydney et al},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Neurological effects in the offspring after switching from tobacco cigarettes to e-cigarettes during pregnancy in a mouse model},

author = {Nguyen T, Li GE, Chen H, Cranfield CC, McGrath KC, GorrieCA.},

url = {https://pubmed.ncbi.nlm.nih.gov/31505003/},

year  = {2019},

date = {2019-08-29},

note = {University of Technology Sydney},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {A novel bone substitute with high bioactivity strength and porosity for repairing large and load-bearing bone defects},

author = {Jiao Jiao Li , Colin R Dunstan, Ali Entezari Qing Li , Roland Steck , Siamak Saifzadeh,, Ameneh Sadeghpour , John R Field Austin Akey, Martin Vielreicher, Oliver Friedrich, Seyed-Iman Roohani-Esfahani , Hala Zreiqat },

url = {https://pubmed.ncbi.nlm.nih.gov/30773833/},

year  = {2019},

date = {2019-08-04},

urldate = {2019-08-04},

note = {Queensland University of Technology, University of Sydney, Kolling Institute et al},

keywords = {Sheep},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Topographic organization of the ‘Third-Tier’ dorsomedial visual cortex in the macaque},

author = {Hadjidimitrakis K, Bakola S, Chaplin TA, Yu HH, Alanazi O, Chan JM, Worthy KH, Rosa MGP.},

url = {https://www.jneurosci.org/content/39/27/5311},

year  = {2019},

date = {2019-07-03},

note = {Monash University},

keywords = {Macaque, Non-human primates},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = { Intermittent fasting increasing energy expenditure and promotes adipose tissue browning in mice},

author = { Liu B, Page AJ, Hutchison AT, Wittert GA, Heilbronn LK.},

url = {https://www.sciencedirect.com/science/article/abs/pii/S0899900719300462?via%3Dihub},

year  = {2019},

date = {2019-06-01},

note = {University of Adelaide, South Australian Health and Medical Research Institute},

keywords = {Mice},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection},

author = {Nedaa Alharbi et al },

url = {https://doi.org/10.1016/j.jcis.2024.02.134},

doi = {10.1016/j.jcis.2024.02.134},

journal = {Journal of Colloid and Interface Science Journal of Colloid and Interface Science},

volume = {663},

pages = {43052},

abstract = {Peptide-based vaccines can trigger highly specific immune responses, although peptides alone are usually unable to confer strong humoral or cellular immunity. Consequently, peptide antigens are administered with immunostimulatory adjuvants, but only a few are safe and effective for human use. To overcome this obstacle, herein a peptide antigen was lipidated to effectively anchor it to liposomes and emulsion. A peptide antigen B cell epitope from Group A Streptococcus M protein was conjugated to a universal T helper epitope, the pan DR-biding epitope (PADRE), alongside a lipidic moiety cholesterol. Compared to a free peptide antigen, the lipidated version (LP1) adopted a helical conformation and self-assembled into small nanoparticles. Surprisingly, LP1 alone induced the same or higher antibody titers than liposomes or emulsion-based formulations. In addition, antibodies produced by mice immunized with LP1 were more opsonic than those induced by administering the antigen with incomplete Freund’s adjuvant. No side effects were observed in the immunized mice and no excessive inflammatory immune responses were detected. Overall, this study demonstrated how simple conjugation of cholesterol to a peptide antigen can produce a safe and efficacious vaccine against Group A Streptococcus – the leading cause of superficial infections and the bacteria responsible for deadly post-infection autoimmune disorders.},

keywords = {},

pubstate = {forthcoming},

tppubtype = {article}

}