Animal-Free Research

Explore the future of biomedical research – a world beyond animal testing. Cutting-edge methods like organ-on-a-chip and in vitro testing are paving the way

Animal-free methods of research offer direct insights into human health.

Curious about these breakthroughs? Continue reading below to discover how these innovative techniques are leading us towards a kinder future.

Animal-Free Research

How E-Cigarettes (“Vaping”) Impacts Airway Cells

Article: Effects of E-cigarette E-liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis Respirology. 2020 Jun;25(6):620-628. Epub 2019 Sep 22. doi: 10.1111/resp.13696 https://onlinelibrary.wiley.com/doi/full/10.1111/resp.13696 Authors: Miranda P Ween 1 2 , Rhys Hamon 1 2 , Matthew G Macowan 1 2 , Leigh Thredgold 3 , Paul N Reynolds 1

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Animal-Free Research

Predicting pre-eclampsia with a survey to estimate sub-optimal health status (SHSQ-25)

Article: Integration of suboptimal health status evaluation as a criterion for prediction of preeclampsia is strongly recommended for healthcare management in pregnancy: a prospective cohort study in a Ghanaian population   EPMA Journal volume 10, pages 211–226(2019) doi: 10.1007/s13167-019-00183-0 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695466/ Authors Enoch Odame Anto 1 2 , Peter Roberts 1

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Animal-Free Research

Brain implant turns thoughts into computer actions for humans with paralysis

Article: Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience Journal of Neurointerventional Surgery 2020; 0-7. First published on 28 October 2020 doi:10.1136/neurintsurg-2020-016862 https://jnis.bmj.com/content/early/2020/10/30/neurintsurg-2020-016862#ref-14 Authors: Thomas J Oxley,1,2 Peter E Yoo,1,2 Gil S Rind,1,2 Stephen M Ronayne,1,2 C M

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Animal-Free Research

Using neurons made from human stem cells to understand how THC affects the genes linked to neuropsychiatric disorders

Article: THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders   Translational Psychiatry volume 8, Article number: 89 (2018) Doi: 10.1038/s41398-018-0137-3 https://www.nature.com/articles/s41398-018-0137-3?source=post_page Authors: Boris Guennewig 1,2,3, Maina Bitar 4, Ifeanyi Obiorah 5,6, James Hanks 5,7,8, Elizabeth A. O’Brien 4, Dominik C. Kaczorowski 3, Yasmin L. Hurd 5,9,

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Animal-Free Research

The survival of SARS-CoV-2 on surfaces at different temperatures

Article: The effect of temperature on persistence of SARS-CoV-2 on common surfaces   Virology Journal 17, Article number: 145 (2020) Doi: 10.1186/s12985-020-01418-7 Published 07 October 2020 https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01418-7 Authors: Shane Riddell, Sarah Goldie, Andrew Hill, Debbie Eagles and Trevor W. Drew Affiliations: Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre

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Animal-Free Research

Melanoma cell cluster “nests” formed by cell proliferation

Article: Three-dimensional experiments and individual based simulations show that cell proliferation drives melanoma nest formation in human skin tissue BMC Syst Biol. 2018; 12: 34. Published online 2018 Mar 27. doi: 10.1186/s12918-018-0559-9 https://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-018-0559-9 Authors: Parvathi Haridas 1,2, Alexander P. Browning 2, Jacqui A. McGovern 1, D. L. Sean McElwain 1,2

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Animal-Free Research

The success of Hsp90 drug inhibitors on human prostate tumours (ex vivo)

Article: Evidence for Efficacy of New Hsp90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors Clinical Cancer Research 2012 Jul 1;18(13):3562-70. doi: 10.1158/1078-0432.CCR-12-0782. Epub 2012 May 9. https://clincancerres.aacrjournals.org/content/18/13/3562.long Authors: Margaret M. Centenera1, Joanna L. Gillis1, Adrienne R. Hanson1, Shalini Jindal1, Renea A. Taylor3, Gail P. Risbridger3, Peter D. Sutherland2, Howard I.

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Animal-Free Research

PET scans reveal metabolic changes in the brain during delirium

Article: 2-18F-fluoro-2-deoxyglucose positron emission tomography in delirium Journal of Cerebral Blood Flow & Metabolism 2017, Vol. 37(11) 3556-3567 Doi: 10.1177/0271678X17701764. Published online Mar 28 2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669345/ Authors: Lucy R Haggstrom,1 Julia A Nelson,2 Eva A Wegner,2 and Gideon A Caplan 1,2 Affiliations: 1 Faculty of Medicine, University of New South

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