Animal-Free Research

Explore the future of biomedical research – a world beyond animal testing. Cutting-edge methods like organ-on-a-chip and in vitro testing are paving the way

Animal-free methods of research offer direct insights into human health.

Curious about these breakthroughs? Continue reading below to discover how these innovative techniques are leading us towards a kinder future.

For researchers - AFSA new branding (3)
Animal-Free Research

Targeted Deep Sequencing for Colorectal Cancer

Article: Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing JNCI Cancer Spectr. 2019;3(2):pkz012. Published 2019 Apr 16. doi:10.1093/jncics/pkz012 Authors: Rebecca C Poulos 1 2, Dilmi Perera 1, Deborah Packham 1, Anushi Shah 1, Caroline Janitz 3, John E Pimanda 1 4 5, Nicholas Hawkins

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Three scientists stare with concentration into microscopes
Animal-Free Research

How Air Pollution is related to Gene Expression

Article: Candidate gene expression in response to low-level air pollution Environment International Volume 140 (2020) 105610 DOI: https://doi.org/10.1016/j.envint.2020.105610 https://www.sciencedirect.com/science/article/pii/S0160412019335512 Authors: Lina Madaniyazi a, b Shanshan Li c, d Shuai Li e, f Yuming Guo c, d Affiliations: a Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki,

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For researchers - AFSA new branding
Animal-Free Research

Two-dimensional neuro MR spectroscopy to detect neurochemical changes in Post-traumatic stress disorder

Article: Post-traumatic stress disorder affects fucose-α(1–2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy Transl Psychiatry. 2019; 9: 27. Published online 2019 Jan 18. doi: 10.1038/s41398-018-0365-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338732/   Authors: Scott Quadrelli,1,2,3,4 Nathan Tosh,1,3 Aaron Urquhart,1 Katie Trickey,1 Rosanna Tremewan,1 Graham Galloway,1 Lisa Rich,1 Rodney Lea,3 Peter Malycha,1 and Carolyn Mountford1,2 Affiliations: Translational Research

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Case studies - animal-free research
Animal-Free Research

How the Paleo Diet is related to Gut Health (Microbiome) and Heart Health

Article: Long term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351840/ Authors: Angela Genoni 1 , Claus T Christophersen 2 3 , Johnny Lo 4 , Megan Coghlan 3 5 , Mary C Boyce 4 , Anthony R Bird

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For researchers and students
Animal-Free Research

Clinicopathological importance of NGF and receptor TrkA profiles in cervical cancer

Article: Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma Annals of Oncology 30: 1071–1079, 2019 doi:10.1093/annonc/mdz132 Published online 15 May 2019 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354692/ Authors: Sam Faulkner, 1 , 2 Nathan Griffin, 1 , 2 Christopher W. Rowe, 2 , 3 Phillip Jobling, 1 , 2 Janine M. Lombard, 3 , 4 Sonia M. Oliveira, 2 Marjorie M. Walker, 2 , 3 and Hubert Hondermarck

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For researchers - Animal-Free Science Advocacy
Animal-Free Research

Investigating the link between fatty tissue build-up in lungs and overweight/obesity (BMI)

Article: Fatty airways: Implications for Obstructive Disease European Respiratory Journal 2019, in press DOI: 10.1183/13993003.00857-2019 https://erj.ersjournals.com/content/54/6/1900857 Authors: John G. Elliot,1,2 Graham M. Donovan,3 Kimberley C.W. Wang,2,4 Francis H.Y. Green,5 Alan L. James,1,6 Peter B. Noble.2 Affiliations: 1West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir

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For researchers - AFSA new branding
Animal-Free Research

The use of discarded canine testicular and uterine tissues for teaching practicals in physiology and pharmacology

Article:  Validation of canine uterine and testicular arteries for the functional characterisation of receptor-mediated contraction as a replacement for laboratory animal tissues in teaching PLoS ONE 15 (5): e0230516. https://doi.org/10.1371/journal. pone.0230516 May 26,2020 1 Authors: Louise Mulcahy, Elizabeth Tudor, Simon R. BaileyID* Affiliations Department of Veterinary Biosciences, Melbourne Veterinary School,

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brain scan stock image research
Animal-Free Research

Exploring the Functional Brain Changes that occur from Sports-Related Concussion using fMRI

Article: Functional brain effects of acute concussion in Australian rules football players Journal of Concussion, vol. 3, First Published July 8, 2019. DOI: 10.1177/2059700219861200 https://journals.sagepub.com/doi/full/10.1177/2059700219861200 Authors: Graeme D Jackson1, 2, 3, 4*, Michael Makdissi1, 5*, Mangor Pedersen1*, Donna M Parker1, Evan K Curwood1, Shawna Farquharson1, Alan Connelly1, 2, David F

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For researchers - Animal-Free Science Advocacy
Animal-Free Research

Whole-genome sequencing to identify genomic instability that contributes to familial Breast Cancer aimed at enhancing targeted therapies for patients.

Article: Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers Annals of Oncology 30: 1071–1079, 2019 doi:10.1093/annonc/mdz132 Published online 15 May 2019 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637375/ Authors: K Nones,1 J Johnson,2 F Newell,1 A M Patch,1 H Thorne,3,4 S H Kazakoff,1 X M de Luca,2 M T Parsons,5 K Ferguson,2 L E Reid,2 A E McCart Reed,2 S Srihari,2,6 V Lakis,1 A

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