Article Fawcett, LK, Chew, ZA, Schneider-Futschik, EK et al. 2025, ‘Predictive capacity of paediatric nasal epithelial cells in sequential CFTR modulator therapy’, Thorax, vol. 81, pp. 548–559. https://thorax.bmj.com/content/81/6/548 Funding Sydney Children’s Hospitals Foundation NHMRC Rebecca L. Cooper Foundation Cystic Fibrosis Australia David Miller Giles Innovation Grant Luminesce Alliance Key terms
Background Sanfilippo syndrome (MPS IIIA) is a form of childhood dementia that leads to progressive cognitive decline, loss of skills, and premature death. In this study, researchers used patient-derived stem cells to model human brain networks. They found that early disease changes are driven by disrupted communication between brain cells,
This study provides strong, human-relevant evidence that GLP-1 drugs help protect the kidney and heart in people with type 2 diabetes, reinforcing the importance of clinical trials over animal studies for human health. Article Badve, SV, Bilal, A, Lee, MMY, Sattar, N, Gerstein, HC, Ruff, CT, McMurray, JJV, Rossing,
Article Autism-related dietary preferences mediate autism-gut microbiome associations. Cell 184, 5916–5931, November 24, 2021, Elsevier Inc., https://doi.org/10.1016/j.cell.2021.10.015 Authors Chloe X. Yap, Anjali K. Henders, Gail A. Alvares, David L.A. Wood, Lutz Krause, Gene W. Tyson, Restuadi Restuadi, Leanne Wallace, Tiana McLaren, Narelle K. Hansell, Dominique Cleary, Rachel Grove, Claire Hafekost,
Article Combined Inhibition of G9a and EZH2 Suppresses Tumor Growth via Synergistic Induction of IL24-Mediated Apoptosis Cancer Research 82 (7) canres.2218.2021-1221 https://doi.org/10.1158/0008-5472.can-21-2218 Authors Casciello, Francesco, Kelly, Gregory M., Ramarao-Milne, Priya, Kamal, Nabilah, Stewart, Teneale A., Mukhopadhyay, Pamela, Kazakoff, Stephen H., Miranda, Mariska, Kim, Dorim, Davis, Felicity M., Hayward, Nicholas K.,
Article Net benefit and cost-effectiveness of universal iron containing multiple micronutrient powders for young children in 78 countries: a microsimulation study Lancet Global Health 2020 Vol 8 e1071-80 Authors Sant-Rayn Pasricha, Adrian Gheorghe, Fayrouz Sakr-Ashour, Amrita Arcot, Lynnette Neufeld, Laura E Murray-Kolb, Parminder S Suchdev, Michael Bode Affiliations Walter and
Summary The study on COPD biomarkers in faecal microbiomes highlights the identification of metabolites that may serve as reliable indicators for chronic obstructive pulmonary disease. Researchers compared the gut microbiomes of COPD patients with healthy controls, revealing distinct differences potentially linked to dietary habits. This human-relevant research underscores the importance
Article Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8+ T cells Clinical & Translational Immunology (2021) https://doi.org/10.1002/cti2.1242 Authors Thi HO Nguyen1 , Julie L McAuley1 , Youry Kim1 , Ming ZM Zheng1 , Nicholas A Gherardin 1,2 , Dale
Article A Taxon-Specific and High-Throughput Method for Measuring Ligand Binding to Nicotinic Acetylcholine Receptors Toxins 2019, 11(10), 600; https://doi.org/10.3390/toxins11100600 Authors Christina N. Zdenek 1,†OrcID,Richard J. Harris 1,†OrcID,Sanjaya Kuruppu 2,†,Nicholas J. Youngman 1,James S. Dobson 1OrcID,Jordan Debono 1,Muzaffar Khan 3,Ian Smith 2,Mike Yarski 4,David Harrich 5,Charlotte Sweeney 6,Nathan Dunstan 7,Luke Allen
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