@article{nokey,
title = {An adjuvanted chimeric spike antigen boosts lung-resident memory T-cells and induces pan-sarbecovirus protective immunity},
author = {Claudio Counoupas, Elizabeth Chan, Paco Pino, Joshua Armitano, Matt D Johansen, Lachlan J Smith, Caroline L Ashley, Eva Estapé, Jean Troyon, Sibel Alca, Stefan Miemczyk, Nicole G Hansbro, Gabriella Scandurra, Warwick J Britton, Thomas Courant, Patrice M Dubois, Nicolas Collin, V Krishna Mohan, Philip M Hansbro, Maria J Wurm, Florian M Wurm, Megan Steain, James A Triccas},
url = {https://www.nature.com/articles/s41541-025-01144-7},
doi = {https://doi.org/10.1038/s41541-025-01144-7},
year = {2025},
date = {2025-05-08},
urldate = {2025-05-08},
journal = {Nature Partner Journals},
volume = {10},
number = {89},
abstract = {To improve protection against evolving COVID-19 variants and future coronaviruses, researchers developed a new vaccine candidate called CoVEXS5. It combines spike protein features from past and predicted virus strains and was produced in lab-grown cells with a squalene-based booster. The vaccine was tested on mice and hamsters, who were infected with various strains of the virus (including Omicron XBB.1.5 and SARS-CoV-1) to assess protection. Animals were monitored for illness, inflammation and immune response, and their tissues were collected for analysis. Some were previously given an mRNA vaccine to test the effects of boosting.},
note = {Sydney Infectious Diseases Institute},
keywords = {COVID-19, Hamsters, Mice},
pubstate = {published},
tppubtype = {article}
}