@article{nokey,
title = {Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening},
author = {Wei Jin, Yexuan Deng, John E La Marca, Emily J Lelliott, Sarah T Diepstraten, Christina König, Lin Tai, Valentina Snetkova, Kristel M Dorighi, Luke Hoberecht, Millicent G Hedditch, Lauren Whelan, Geraldine Healey, Dan Fayle, Kieran Lau, Margaret A Potts, Moore Z Chen, Angus P R Johnston, Yang Liao, Wei Shi, Andrew J Kueh, Benjamin Haley, Jean-Philippe Fortin, Marco J Herold },
url = {https://www.nature.com/articles/s41467-025-56282-2},
doi = {https://doi.org/10.1038/s41467-025-56282-2},
year = {2025},
date = {2025-01-30},
urldate = {2025-01-30},
journal = {Nature Communications},
volume = {16},
number = {974},
abstract = {Scientists developed a genetically modified mouse that continuously produces the gene-editing tool Cas12a, allowing them to edit genes in living animals, including for cancer research. They created gene-editing libraries to study gene function and analysed immune cells from the spleen, bone marrow and lymph nodes using flow cytometry. Some mice received bone marrow transplants after radiation to study blood cell regeneration, while others developed lymphoma and were euthanised for further study. Scientists also switched specific genes on or off in immune cells to investigate their role in disease and immunity.},
note = {Olivia Newton-John Cancer Research Institute, Heidelberg, Melbourne, Australia},
keywords = {Gene-editing, Mice},
pubstate = {published},
tppubtype = {article}
}